Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers

Noncoding RNA. 2021 Feb 17;7(1):13. doi: 10.3390/ncrna7010013.


: All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.

Keywords: development; disease; lncRNAs; microRNAs; retinoic acid.

Publication types

  • Review