Dietary Acrylamide Intake and the Risks of Renal Cell, Prostate, and Bladder Cancers: A Japan Public Health Center-Based Prospective Study

Nutrients. 2021 Feb 27;13(3):780. doi: 10.3390/nu13030780.


Acrylamide can be carcinogenic to humans. However, the association between the acrylamide and the risks of renal cell, prostate, and bladder cancers in Asians has not been assessed. We aimed to investigate this association in the Japan Public Health Center-based Prospective Study data in 88,818 Japanese people (41,534 men and 47,284 women) who completed a food frequency questionnaire in the five-year follow-up survey in 1995 and 1998. A validated food frequency questionnaire was used to assess the dietary acrylamide intake. Cox proportional hazard regression models were used to estimate hazard ratios and 95% confidence intervals (CIs). During a mean follow-up of 15.5 years (15.2 years of prostate cancer), 208 renal cell cancers, 1195 prostate cancers, and 392 bladder cancers were diagnosed. Compared to the lowest quintile of acrylamide intake, the multivariate hazard ratios for the highest quintile were 0.71 (95% CI: 0.38-1.34, p for trend = 0.294), 0.96 (95% CI: 0.75-1.22, p for trend = 0.726), and 0.87 (95% CI: 0.59-1.29, p for trend = 0.491) for renal cell, prostate, and bladder cancers, respectively, in the multivariate-adjusted model. No significant associations were observed in the stratified analyses based on smoking. Dietary acrylamide intake was not associated with the risk of renal cell, prostate, and bladder cancers.

Keywords: acrylamide; cohort; diet; prostate and bladder cancer; renal cell.

MeSH terms

  • Acrylamide / administration & dosage
  • Acrylamide / toxicity*
  • Adult
  • Aged
  • Carcinoma, Renal Cell / chemically induced*
  • Carcinoma, Renal Cell / epidemiology
  • Cohort Studies
  • Data Collection
  • Diet
  • Female
  • Food Contamination
  • Humans
  • Japan / epidemiology
  • Kidney Neoplasms / chemically induced*
  • Kidney Neoplasms / epidemiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Prostatic Neoplasms / chemically induced*
  • Prostatic Neoplasms / epidemiology
  • Public Health Administration
  • Risk Factors
  • Surveys and Questionnaires
  • Urinary Bladder Neoplasms / chemically induced*


  • Acrylamide