Peroxisomes as cellular adaptors to metabolic and environmental stress

Trends Cell Biol. 2021 Aug;31(8):656-670. doi: 10.1016/j.tcb.2021.02.005. Epub 2021 Mar 2.


Peroxisomes are involved in multiple metabolic processes, including fatty acid oxidation, ether lipid synthesis, and reactive oxygen species (ROS) metabolism. Recent studies suggest that peroxisomes are critical mediators of cellular responses to various forms of stress, including oxidative stress, hypoxia, starvation, cold exposure, and noise. As dynamic organelles, peroxisomes can modulate their proliferation, morphology, and movement within cells, and engage in crosstalk with other organelles in response to external cues. Although peroxisome-derived hydrogen peroxide has a key role in cellular signaling related to stress, emerging studies suggest that other products of peroxisomal metabolism, such as acetyl-CoA and ether lipids, are also important for metabolic adaptation to stress. Here, we review molecular mechanisms through which peroxisomes regulate metabolic and environmental stress.

Keywords: ether lipid; lipid metabolism; peroxisome; plasmalogen; reactive oxygen species; stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Lipid Metabolism
  • Oxidation-Reduction
  • Oxidative Stress*
  • Peroxisomes* / metabolism
  • Reactive Oxygen Species / metabolism


  • Reactive Oxygen Species