Uncloaking Breast Tumor Neoantigens with Radiation

Abstract

Currently, immunotherapy is not effective for all cancer patients, partly due to an inability to mount sufficient tumor-specific T cell responses. Here, we highlight a recent study by Lhuillier et al. demonstrating that radiation potentiates neoantigen expression, eliciting CD4⁺ and CD8⁺ T cell responses and tumor growth control in mice.