Uncloaking Breast Tumor Neoantigens with Radiation

Trends Immunol. 2021 Apr;42(4):277-279. doi: 10.1016/j.it.2021.02.009. Epub 2021 Mar 3.

Abstract

Currently, immunotherapy is not effective for all cancer patients, partly due to an inability to mount sufficient tumor-specific T cell responses. Here, we highlight a recent study by Lhuillier et al. demonstrating that radiation potentiates neoantigen expression, eliciting CD4+ and CD8+ T cell responses and tumor growth control in mice.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antigens, Neoplasm*
  • Breast Neoplasms* / radiotherapy
  • Humans
  • Immunotherapy
  • Mice
  • T-Lymphocytes

Substances

  • Antigens, Neoplasm