Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice

Jpn J Pharmacol. 1988 Jan;46(1):93-6. doi: 10.1254/jjp.46.93.


Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CAy mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CAy) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CAy mice were significantly different from the PR one in alloxan-mice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.

MeSH terms

  • Aging / physiology
  • Animals
  • Blood Glucose / metabolism
  • Blood Pressure*
  • Diabetes Mellitus, Experimental / physiopathology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pulse*


  • Blood Glucose