Effects of polycyclic aromatic hydrocarbons and multiple metals co-exposure on the mosaic loss of chromosome Y in peripheral blood

Yansen Bai; Xin Guan; Wei Wei; Yue Feng; Hua Meng; Guyanan Li; Hang Li; Mengying Li; Chenming Wang; Ming Fu; Jiali Jie; Xiaomin Zhang; Meian He; Huan Guo

doi:10.1016/j.jhazmat.2021.125519

Effects of polycyclic aromatic hydrocarbons and multiple metals co-exposure on the mosaic loss of chromosome Y in peripheral blood

J Hazard Mater. 2021 Jul 15:414:125519. doi: 10.1016/j.jhazmat.2021.125519. Epub 2021 Feb 24.

Authors

Yansen Bai¹, Xin Guan¹, Wei Wei¹, Yue Feng¹, Hua Meng¹, Guyanan Li¹, Hang Li¹, Mengying Li¹, Chenming Wang¹, Ming Fu¹, Jiali Jie¹, Xiaomin Zhang¹, Meian He¹, Huan Guo²

Affiliations

¹ Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
² Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: ghuan5011@hust.edu.cn.

PMID: 33676251
DOI: 10.1016/j.jhazmat.2021.125519

Abstract

Mosaic loss of chromosome Y (mLOY) is an indicator of genome instability, but the environmental stressors of mLOY remained largely unknown. In this study, we detected the internal exposure levels of 11 polycyclic aromatic hydrocarbon (PAH) metabolites and 22 metals among 888 coke-oven workers, and calculated their blood mLOY based on genome-wide SNP genotyping data and presented as median log R ratio (mLRR-Y). The generalized linear model (GLM), LASSO, and Bayesian kernel machine regression (BKMR), were used to select mLOY-relevant chemicals. The results of these models consistently suggested the negative dose-response relationships of urinary 1-hydroxynaphthalene (1-OHNa), antimony (Sb), and molybdenum (Mo) with mLRR-Y. There were no pairwise interactions between these three chemicals (P_interaction > 0.05), but subjects with high exposure to ≥ 2 kinds of these chemicals showed reducing mLRR-Y [β(95%CI) = - 0.015(- 0.023, - 0.008)], increasing oxidative DNA damage (marked by 8-hydroxydeoxyguanosine) [β(95%CI) = 0.625(0.454, 0.796)] and chromosome damage (marked by micronucleus frequency in lymphocytes) [frequency ratio (FR) and 95%CI = 1.146(1.047, 1.225)] than those with low exposure to all these chemicals. The combined effects of 1-OHNa, Sb, and Mo on elevating DNA damage may partly explain their joint effects on increased blood mLOY. These results provided a new insight into environmental hazards co-exposure on chromosome-Y deletions.

Keywords: DNA damage; Joint effects; Metals; Mosaic loss of chromosome Y; Polycyclic aromatic hydrocarbons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bayes Theorem
Chromosomes, Human, Y
Coke*
Humans
Male
Mosaicism
Occupational Exposure* / analysis
Polycyclic Aromatic Hydrocarbons* / toxicity

Substances

Coke
Polycyclic Aromatic Hydrocarbons