Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI

Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101599. doi: 10.1016/j.clinre.2020.101599. Epub 2021 Mar 3.


Thiazide diuretics are prescribed daily and rarely hepatotoxic. We report the case of 86-year-old woman who was admitted in hospital for jaundice after taking hydrochlorothiazide. All differential diagnoses have been eliminated. The liver biopsy was compatible with drug-induced hepatitis. Clinical and biological manifestations improved after discontinuation of the treatment. The reported case is compared to three other cases in the literature.

Keywords: Acute hepatitis; DILI; Hepatotoxicity; Hydrochlorothiazide; Thiazide diuretics.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Biopsy
  • Chemical and Drug Induced Liver Injury* / diagnosis
  • Chemical and Drug Induced Liver Injury* / etiology
  • Diagnosis, Differential
  • Female
  • Humans
  • Hydrochlorothiazide* / adverse effects


  • Hydrochlorothiazide