Effect of Insurance Status on Outcomes of Acute Ischemic Stroke Patients Receiving Intra-Arterial Treatment: Results from the Paul Coverdell National Acute Stroke Program

J Stroke Cerebrovasc Dis. 2021 May;30(5):105692. doi: 10.1016/j.jstrokecerebrovasdis.2021.105692. Epub 2021 Mar 4.

Abstract

Background: Stroke continues to be a leading cause of death and disability in the United States. Rates of intra-arterial reperfusion treatments (IAT) for acute ischemic stroke (AIS) are increasing, and these treatments are associated with more favorable outcomes. We sought to examine the effect of insurance status on outcomes for AIS patients receiving IAT within a multistate stroke registry.

Methods: We used data from the Paul Coverdell National Acute Stroke Program (PCNASP) from 2014 to 2019 to quantify rates of IAT (with or without intravenous thrombolysis) after AIS. We modeled outcomes based on insurance status: private, Medicare, Medicaid, or no insurance. Outcomes were defined as rates of discharge to home, in-hospital death, symptomatic intracranial hemorrhage (sICH), or life-threatening hemorrhage during hospitalization.

Results: During the study period, there were 486,180 patients with a clinical diagnosis of AIS (mean age 70.6 years, 50.3% male) from 674 participating hospitals in PCNASP. Only 4.3% of patients received any IAT. As compared to private insurance, uninsured patients receiving any IAT were more likely to experience in-hospital death (AOR 1.36 [95% CI 1.07-1.73]). Medicare (AOR 0.78 [95% CI 0.71-0.85]) and Medicaid (AOR 0.85 [95% CI 0.75-0.96]) beneficiaries were less likely but uninsured patients were more likely (AOR 1.90 [95% CI 1.61-2.24]) to be discharged home. Insurance status was not found to be independently associated with rates of sICH.

Conclusions: Insurance status was independently associated with in-hospital death and discharge to home among AIS patients undergoing IAT.

Keywords: Insurance status; Intra-arterial treatment; Ischemic stroke; Outcomes.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Endovascular Procedures* / adverse effects
  • Endovascular Procedures* / mortality
  • Female
  • Fibrinolytic Agents / administration & dosage*
  • Fibrinolytic Agents / adverse effects
  • Healthcare Disparities*
  • Hospital Mortality
  • Humans
  • Insurance, Health*
  • Intracranial Hemorrhages / etiology
  • Intracranial Hemorrhages / mortality
  • Ischemic Stroke / diagnosis
  • Ischemic Stroke / drug therapy*
  • Ischemic Stroke / mortality
  • Male
  • Medicaid
  • Medically Uninsured*
  • Medicare
  • Middle Aged
  • Patient Discharge
  • Registries
  • Risk Assessment
  • Risk Factors
  • Thrombolytic Therapy* / adverse effects
  • Time Factors
  • Treatment Outcome
  • United States / epidemiology
  • Young Adult

Substances

  • Fibrinolytic Agents