Research progress in influence of perioperative hypotension on postoperative outcome of patients

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jan 28;46(1):84-90. doi: 10.11817/j.issn.1672-7347.2021.200448.
[Article in English, Chinese]

Abstract

With the advancement of disease treatments, the number of patients undergoing surgery worldwide is increasing. However, many patients still experience severe perioperative complications. Perioperative hypotension is one of the common side effects during surgery. Physiologically, perioperative hypotension can lead to insufficient perfusion of important organs and result in acute and chronic irreversible organ injury, which cause serious consequences for the patient's postoperative hospitalization and even the long-term outcome. Therefore, in order to optimize perioperative circulation management and improve the quality of life for patients after surgery, it is of great importance to investigate the relationship between perioperative hypotension and postoperative myocardial injury, ischemic stroke, postoperative delirium, acute kidney injury, and postoperative mortality. Individualized circulation management and reasonable application of vasoactive drugs may be the key point to early prevention and correct treatment of perioperative hypotension, which is of great significance for reducing perioperative related morbidity and mortality and improving the prognosis for the surgical patients.

随着疾病治疗手段的进步,全球接受手术治疗的患者逐渐增加。但是,仍然有许多患者存在严重的围手术期并发症。在麻醉手术期间常发生围手术期低血压,进而可能导致重要器官的灌注不足,引起机体急慢性不可逆损伤,从而对患者短期及长期的术后转归产生严重的影响。因此,为了优化围手术期循环管理策略和提高手术患者的术后生存质量,探究围手术期低血压对患者术后心肌损伤、缺血性卒中、术后谵妄、急性肾损伤和术后死亡率的影响极为重要。个体化的循环管理以及血管活性药物的合理应用可能是围手术期低血压早期预防和及时、正确治疗的关键,对降低围手术期死亡率及改善手术患者预后具有重要的意义。.

Keywords: acute kidney injury; ischemic stroke; perioperative hypotension; postoperative myocardial injury; postoperative outcome.

MeSH terms

  • Acute Kidney Injury* / epidemiology
  • Acute Kidney Injury* / etiology
  • Humans
  • Hypotension* / etiology
  • Postoperative Complications / epidemiology
  • Postoperative Complications / etiology
  • Quality of Life