Ramucirumab-related Oral Pyogenic Granuloma: A Report of Two Cases

Intern Med. 2021 Aug 15;60(16):2601-2605. doi: 10.2169/internalmedicine.6650-20. Epub 2021 Mar 8.


Pyogenic granuloma (PG) is a granulomatous elevated lesion that occurs on the skin and mucous membranes. We herein report two cases of intra-oral PG that developed during the administration of ramucirumab for gastric cancer. Case 1 involved a 55-year-old man with a 6-mm tumor on the right tongue, and case 2 involved a 67-year-old man with a 5-mm tumor on the upper lip. The imbalance in angiogenesis caused by ramucirumab and the deterioration in the local oral environment were suggested to have caused the PG. Medical and dental collaboration is essential during the administration of ramucirumab.

Keywords: VEGFR2; medical and dental collaboration; oral management; pyogenic granuloma; ramucirumab.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Granuloma, Pyogenic* / chemically induced
  • Granuloma, Pyogenic* / diagnosis
  • Humans
  • Lip
  • Male
  • Middle Aged
  • Mouth Mucosa
  • Ramucirumab


  • Antibodies, Monoclonal, Humanized