Update on Nanoparticle-Based Drug Delivery System for Anti-inflammatory Treatment

Huailan Wang; Yunxiang Zhou; Qunan Sun; Chenghao Zhou; Shiyao Hu; Cameron Lenahan; Weilin Xu; Yongchuan Deng; Gonghui Li; Sifeng Tao

doi:10.3389/fbioe.2021.630352

Update on Nanoparticle-Based Drug Delivery System for Anti-inflammatory Treatment

Front Bioeng Biotechnol. 2021 Feb 17:9:630352. doi: 10.3389/fbioe.2021.630352. eCollection 2021.

Authors

Huailan Wang¹, Yunxiang Zhou², Qunan Sun³, Chenghao Zhou¹, Shiyao Hu⁴, Cameron Lenahan^{5

6}, Weilin Xu⁷, Yongchuan Deng², Gonghui Li¹, Sifeng Tao²

Affiliations

¹ Department of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
² Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Department of Medical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁴ School of Medicine, Zhejiang University, Hangzhou, China.
⁵ Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, CA, United States.
⁶ Burrell College of Osteopathic Medicine, Las Cruces, NM, United States.
⁷ Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Nanobiotechnology plays an important role in drug delivery, and various kinds of nanoparticles have demonstrated new properties, which may provide opportunities in clinical treatment. Nanoparticle-mediated drug delivery systems have been used in anti-inflammatory therapies. Diseases, such as inflammatory bowel disease, rheumatoid arthritis, and osteoarthritis have been widely impacted by the pathogenesis of inflammation. Efficient delivery of anti-inflammatory drugs can reduce medical dosage and improve therapeutic effect. In this review, we discuss nanoparticles with potential anti-inflammatory activity, and we present a future perspective regarding the application of nanomedicine in inflammatory diseases.

Keywords: anti-inflammatory; drug delivery; inflammatory disease; inorganic NPs; nanoparticle; organic NPs.

Publication types

Review