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Observational Study
. 2021 Jun 1;175(6):632-634.
doi: 10.1001/jamapediatrics.2020.6098.

Persistence of Δ-9-Tetrahydrocannabinol in Human Breast Milk

Erica M Wymore  1 , Claire Palmer  1 , George S Wang  1 , Torri D Metz  2 , David W A Bourne  3 , Cristina Sempio  4 , Maya Bunik  1
Affiliations
Observational Study

Persistence of Δ-9-Tetrahydrocannabinol in Human Breast Milk

Erica M Wymore et al. JAMA Pediatr. .

Abstract

This cohort study measures Δ-9-tetrahydrocannabinol levels in breast milk and serum samples from women who were newly abstinent from marijuana and had just delivered an infant.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Wymore reports receiving speaking honoraria related to this subject from the Human Milk Banking Association of North America, Western Society of Pediatric Research, and California Association of Neonatologists Annual Meetings and grants from Colorado Department of Public Health and Environment, Children’s Hospital Colorado Research Institute, and Colorado Fetal Care Center during the conduct of the study. Dr Wang has received royalties from UpToDate on related subjects and is a coinvestigator on a study funded by the National Institute on Drug Abuse (grant 1R01DA045051-01A1). Dr Metz was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development grant K12HD001271 during the completion of this work and reported grants from National Institutes of Health and the Colorado Department of Public Health and Environment during the conduct of the study. Outside of the submitted work, Dr Metz reports that she is or was a site principal investigator for a Pfizer respiratory syncytial virus vaccination trial (for which her institution receives funding), a study to validate a Gestvision preeclampsia point-of-care test, a Novavax respiratory syncytial virus vaccination trial (for which her institution received funding), and a Novartis/GlaxoSmithKline group B streptococcus vaccination trial (for which her institution received funding); she also receives royalties for 2 topics for UpToDate. Dr Sempio reports grant support from the Colorado Department of Public Health and Environment during completion of this study. No other disclosures were reported.

Figures

Figure.
Figure.. Pharmacokinetic Modeling for the Estimated Time to Elimination of Δ-9-Tetrahydrocannabinol (THC) in Breast Milk Following Delivery
Values represented with open shapes were omitted from the time-to-elimination analysis of THC in breast milk. The initial values for patient 7 were omitted until a peak THC level in breast milk was measured, and subsequent declining values were included in the time-to-elimination analysis.
See this image and copyright information in PMC

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References

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