Off-label Use of Direct Oral Anticoagulants in Patients Receiving Surgical Mechanical and Bioprosthetic Heart Valves

JAMA Netw Open. 2021 Mar 1;4(3):e211259. doi: 10.1001/jamanetworkopen.2021.1259.

Abstract

This cohort study assesses direct oral anticoagulant use in patients with surgical prosthetic heart valves in the United States and evaluates differences in preoperative and postoperative profiles in patients discharged while receiving direct oral anticoagulant vs warfarin.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anticoagulants / administration & dosage*
  • Bioprosthesis*
  • Female
  • Follow-Up Studies
  • Heart Valve Diseases / surgery*
  • Heart Valve Prosthesis*
  • Humans
  • Male
  • Middle Aged
  • Off-Label Use / statistics & numerical data*
  • Postoperative Complications / prevention & control*
  • Retrospective Studies
  • Thrombosis / prevention & control*

Substances

  • Anticoagulants