Paraganglioma Presenting as Hypoxia and Syncope in Pregnancy: A Case Report

A A Pract. 2021 Mar 8;15(3):e01411. doi: 10.1213/XAA.0000000000001411.


Paragangliomas (PGLs) are rare tumors with an incidence of 0.007% in pregnant women. Patients with PGLs commonly present with hypertension and tachycardia. This case report describes the evaluation and management of a multiparous woman at 32 weeks of gestation with syncope, hypoxia, and tachycardia as unusual presenting symptoms of PGL. Her symptoms were attributable to paradoxical effects of circulating catecholamines on downregulated alpha-adrenergic receptors resulting in decreased systemic vascular resistance.

Publication types

  • Case Reports

MeSH terms

  • Catecholamines
  • Female
  • Humans
  • Hypoxia / etiology
  • Paraganglioma* / complications
  • Paraganglioma* / diagnosis
  • Paraganglioma* / surgery
  • Pregnancy
  • Syncope / etiology


  • Catecholamines