riboCIRC: a comprehensive database of translatable circRNAs

Genome Biol. 2021 Mar 8;22(1):79. doi: 10.1186/s13059-021-02300-7.

Abstract

riboCIRC is a translatome data-oriented circRNA database specifically designed for hosting, exploring, analyzing, and visualizing translatable circRNAs from multi-species. The database provides a comprehensive repository of computationally predicted ribosome-associated circRNAs; a manually curated collection of experimentally verified translated circRNAs; an evaluation of cross-species conservation of translatable circRNAs; a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function; and a genome browser to visualize the context-specific occupant footprints of circRNAs. It represents a valuable resource for the circRNA research community and is publicly available at http://www.ribocirc.com .

Keywords: CircRNAs; Ribosome profiling; Translatable circRNAs; circRNA-encoded peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology / methods*
  • Data Curation
  • Databases, Genetic*
  • Humans
  • Open Reading Frames
  • Peptides / genetics
  • Protein Biosynthesis
  • RNA, Circular*
  • Ribosomes*
  • Software*
  • User-Computer Interface
  • Web Browser

Substances

  • Peptides
  • RNA, Circular