Judging a Fish by Its Ability to Climb a Tree? A Call for Novel Endpoints in the Appraisal of Ablative Local Treatments of Oligometastatic Cancer

Mauro Loi; Marco Alifano; Marta Scorsetti; Joost J Nuyttens; Lorenzo Livi

doi:10.1002/onco.13747

Judging a Fish by Its Ability to Climb a Tree? A Call for Novel Endpoints in the Appraisal of Ablative Local Treatments of Oligometastatic Cancer

Oncologist. 2021 Jun;26(6):e1085-e1086. doi: 10.1002/onco.13747. Epub 2021 Apr 9.

Authors

Mauro Loi¹, Marco Alifano², Marta Scorsetti^{3

4}, Joost J Nuyttens⁵, Lorenzo Livi¹

Affiliations

¹ Radiotherapy Department, University of Florence, Florence, Italy.
² Thoracic Surgery Department, Cochin Hospital, APHP Centre and INSERM U1138 Team "Cancer, Immune Control, and Escape", Cordeliers Research Center, Paris-Decartes University, Paris, France.
³ Department of Radiotherapy, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
⁴ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
⁵ Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Abstract

This commentary addresses the need for novel endpoints in clinical research to assess the added value of local treatment of metastases in oligometastatic patients and in patients experiencing limited metastatic progression during systemic therapy (oligoprogressive). Novel metrics are proposed for future implementation in clinical trials.

Publication types

Letter

MeSH terms

Carcinoma, Non-Small-Cell Lung*
Humans
Lung Neoplasms* / surgery
Neoplasm Metastasis
Radiosurgery*
Trees