Intensity-modulated radiation therapy for nasal cavity and paranasal sinus tumors: Experience from a single institute

Head Neck. 2021 Jul;43(7):2045-2057. doi: 10.1002/hed.26669. Epub 2021 Mar 9.


Background: To assess the efficacy of intensity-modulated radiation therapy (IMRT) for tumors of the nasal cavity and paranasal sinus (PNS) region.

Materials and methods: Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis.

Results: Fifty-one (24.1%) received definitive RT/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow-up was 43.5 months. The 5-year local control (LC), event-free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated/poorly differentiated histology were associated with inferior 5-year LC, EFS, and OS. Four patients had late Grade 3/Grade 4 ocular toxicity.

Conclusions: IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.

Keywords: IMRT; long-term outcomes; nasal cavity tumors; paranasal sinus tumors; toxicity.

MeSH terms

  • Humans
  • Nasal Cavity
  • Nose Neoplasms* / radiotherapy
  • Paranasal Sinus Neoplasms* / radiotherapy
  • Radiotherapy Dosage
  • Radiotherapy, Intensity-Modulated* / adverse effects
  • Retrospective Studies