Urine proteome of COVID-19 patients

Yanchang Li; Yihao Wang; Huiying Liu; Wei Sun; Baoqing Ding; Yinghua Zhao; Peiru Chen; Li Zhu; Zhaodi Li; Naikang Li; Lei Chang; Hengliang Wang; Changqing Bai; Ping Xu

doi:10.1016/j.urine.2021.02.001

Urine proteome of COVID-19 patients

Urine (Amst). 2020:2:1-8. doi: 10.1016/j.urine.2021.02.001. Epub 2021 Mar 5.

Authors

Yanchang Li¹, Yihao Wang^{1

2}, Huiying Liu³, Wei Sun¹, Baoqing Ding⁴, Yinghua Zhao¹, Peiru Chen¹, Li Zhu⁵, Zhaodi Li¹, Naikang Li¹, Lei Chang¹, Hengliang Wang⁵, Changqing Bai³, Ping Xu^{1

6

7}

Affiliations

¹ State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing, 102206, China.
² Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China.
³ The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
⁴ Department of Ecology and Evolutionary Biology, University of Connecticut, 75 North Eagleville Road, Unit 3043, Storrs, CT, 06269, USA.
⁵ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, 100071, China.
⁶ Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
⁷ Guizhou University School of Medicine, Guiyang, 550025, China.

Abstract

The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-19 positive patients with comorbidities can be clearly differentiated. Multiple pathways have been compromised after the COVID-19 infection, including the dysregulation of complement activation, platelet degranulation, lipoprotein metabolic process and response to hypoxia. This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application in auxiliary diagnosis of COVID-19.

Keywords: COVID-19; Proteomics; Urine.