Transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates

Abstract

Hematopoietic stem cells (HSCs) are the foundation of adult hematopoiesis that produce all types of mature blood lineages. In vertebrates, HSC development is a stepwise process, coordinately regulated by chromatin architectures and a group of transcriptional and epigenetic regulators. A deeper understanding of the molecular mechanisms governing the generation, expansion, and function of HSCs holds great promise in the generation and expansion of engraftable HSCs in vitro for clinical applications. This study reviewed recent advances in transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates.

Keywords: Epigenetic modifications; Hematopoietic stem cell development; Lineage tracing; Signaling; Single cell omics; Transcription factors.