Renal tubular damage after renal stone treatment

Urol Res. 1988;16(2):101-4. doi: 10.1007/BF00261965.


50 patients were studied with respect to renal tubular damage related to open operative, percutaneous and extracorporeal shock wave treatment of renal stones. Preoperative and postoperative urinary N-acetyl-glucosaminidase (NAG) levels were measured as a marker of renal damage. There was no significant evidence of renal tubular damage in patients who underwent a conventional or percutaneous nephrolithotomy; urinary NAG excretion was significantly increased after ischaemic surgery. After extracorporeal shock wave lithotripsy (ESWL) serum NAG levels increased, probably because a damage of the white blood cells in cutaneous and renal circulation, but a slight increase of urinary NAG excretion could suggest a mild renal tubular damage especially in case of more than 2,000 shocks.

MeSH terms

  • Acetylglucosaminidase / urine
  • Creatine Kinase / analysis
  • Humans
  • Isoenzymes
  • Kidney Calculi / pathology
  • Kidney Calculi / therapy*
  • Kidney Tubules / enzymology
  • Kidney Tubules / pathology*
  • L-Lactate Dehydrogenase / analysis
  • Lithotripsy


  • Isoenzymes
  • L-Lactate Dehydrogenase
  • Creatine Kinase
  • Acetylglucosaminidase