Antibodies to liver specific lipoprotein (ALSP) were determined in the blood of 76 children suffering from virus hepatitis A, 22 children with virus hepatitis B and 30 normal children (controls) by enzyme-binding immunosorption for the elucidation of relationships between autoimmunization to hepatic cell plasma membranes and the course of the disease. The results showed ALSP to be present in 25-27% of the examined subjects, being of prognostic importance for the detection of protracted or chronic forms of virus hepatitis.