Smooth Muscle Cell-Specific PKM2 (Pyruvate Kinase Muscle 2) Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1724-1737. doi: 10.1161/ATVBAHA.121.316021. Epub 2021 Mar 11.

Abstract

[Figure: see text].

Keywords: glycolysis; hyperplasia; neointima; phenotype; pyruvate kinase muscle 2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Carotid Artery Injuries / enzymology*
  • Carotid Artery Injuries / genetics
  • Carotid Artery Injuries / pathology
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Cell Movement*
  • Cell Proliferation*
  • Cells, Cultured
  • Disease Models, Animal
  • Enzyme Activation
  • Female
  • Glycolysis
  • Humans
  • Hyperplasia
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Muscle, Smooth, Vascular / enzymology*
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / enzymology*
  • Myocytes, Smooth Muscle / pathology
  • Neointima*
  • Phenotype
  • Pyruvate Kinase / genetics
  • Pyruvate Kinase / metabolism*
  • Signal Transduction
  • Thyroid Hormone-Binding Proteins
  • Thyroid Hormones / genetics
  • Thyroid Hormones / metabolism*

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Thyroid Hormones
  • Pkm protein, mouse
  • Pyruvate Kinase