The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

Nat Genet. 2021 Apr;53(4):420-425. doi: 10.1038/s41588-021-00783-5.


We present the Polygenic Score (PGS) Catalog (, an open resource of published scores (including variants, alleles and weights) and consistently curated metadata required for reproducibility and independent applications. The PGS Catalog has capabilities for user deposition, expert curation and programmatic access, thus providing the community with a platform for PGS dissemination, research and translation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benchmarking
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology
  • Computational Biology / methods
  • Databases, Genetic*
  • Female
  • Genetic Predisposition to Disease
  • Genome, Human
  • Genome-Wide Association Study
  • Humans
  • Male
  • Metadata / statistics & numerical data*
  • Multifactorial Inheritance*
  • Reproducibility of Results
  • Software*