A new screening method for identifying chemosensory receptors responding to agonist

Biosci Biotechnol Biochem. 2021 May 25;85(6):1521-1525. doi: 10.1093/bbb/zbab035.

Abstract

Humans sense taste and smell of various chemical substances through approximately 430 chemosensory receptors. The overall picture of ligand-chemosensory receptor interactions has been partially clarified because of numerous interactions. This study presents a new method that enables a rapid and simple screening of chemosensory receptors. It would be useful for identifying chemosensory receptors activated by taste and odor substances.

Keywords: GFP reporter assay; chemosensory receptor; receptor screening; single cell sorting.

MeSH terms

  • Drug Evaluation, Preclinical / methods*
  • Olfactory Perception / drug effects*
  • Taste Perception / drug effects*