Response to Trimethoprim-Sulfamethoxazole in a Pediatric Hematopoietic Stem Cell Transplant Recipient With Disseminated Toxoplasmosis: A Case Report

Aslam Khan; Hayden T Schwenk; Krystal Kohlman; Alice Bertaina; Stephanie Cho; Jose G Montoya; Despina Contopoulos-Ioannidis

doi:10.1093/jpids/piab006

Response to Trimethoprim-Sulfamethoxazole in a Pediatric Hematopoietic Stem Cell Transplant Recipient With Disseminated Toxoplasmosis: A Case Report

J Pediatric Infect Dis Soc. 2021 Aug 14;10(6):745-748. doi: 10.1093/jpids/piab006.

Authors

Aslam Khan^{1

2}, Hayden T Schwenk^{1

2}, Krystal Kohlman¹, Alice Bertaina^{1

3}, Stephanie Cho⁴, Jose G Montoya⁵, Despina Contopoulos-Ioannidis^{1

2

5}

Affiliations

¹ Lucile Packard Children's Hospital Stanford, Palo Alto, California, USA.
² Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA.
³ Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
⁴ Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, USA.
⁵ Dr. Jack S. Remington Laboratory for Specialty Diagnostics, Palo Alto Medical Foundation, Palo Alto, California, USA.

PMID: 33693793
DOI: 10.1093/jpids/piab006

Abstract

We describe the presentation and treatment of a patient who developed ongoing fever and diagnosed with disseminated toxoplasmosis post-hematopoietic stem cell transplantation. He was initially treated with trimethoprim-sulfamethoxazole (TMP-SMX) and there was dramatic improvement in his fever curve. He successfully completed a modified course of therapy.

Keywords: TMP-SMX; bone marrow transplant; hematopoietic; stem cell transplant; toxoplasma; trimethoprim-sulfamethoxazole.

© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Publication types

Case Reports

MeSH terms

Child
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Toxoplasmosis* / diagnosis
Toxoplasmosis* / drug therapy
Transplant Recipients
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use

Substances

Trimethoprim, Sulfamethoxazole Drug Combination