Multiple sclerosis, solvents, and pets. A case-referent study

Arch Neurol. 1988 Jun;45(6):620-3. doi: 10.1001/archneur.1988.00520300038015.


The effect of potential risk factors for multiple sclerosis was evaluated in a case-referent study that encompassed 83 cases and 467 randomized referents. Information on exposure was obtained by questionnaires that were mailed to the subjects. Mantel-Haenszel rate ratios were increased for males for occupational exposure to solvents and welding and for females for leisure time contact with dogs and caged birds. For both sexes, x-ray film examination occurred more frequently among cases than referents, possibly as an effect of early symptoms from the disease itself.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Animals, Domestic*
  • Humans
  • Middle Aged
  • Multiple Sclerosis / etiology*
  • Solvents / adverse effects*


  • Solvents