Acute posterior multifocal placoid pigment epitheliopathy and cerebral vasculitis

Arch Ophthalmol. 1988 Jun;106(6):796-800. doi: 10.1001/archopht.1988.01060130866042.


Four cases of suspected cerebral vasculitis have been described in association with acute posterior multifocal placoid pigment epitheliopathy, but none was confirmed histopathologically. We describe a patient who developed fatal cerebral vasculitis after placoid pigment epitheliopathy. Histopathologic data revealed a focal granulomatous inflammation of medium-sized arteries in the leptomeninges. Multinucleated giant cells were a conspicuous part of the inflammatory reaction. The cause of both placoid pigment epitheliopathy and cerebral vasculitis remains obscure.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Brain Diseases / complications*
  • Brain Diseases / pathology
  • Eye Diseases / complications*
  • Eye Diseases / pathology
  • Humans
  • Male
  • Pigment Epithelium of Eye* / pathology
  • Vasculitis / complications*
  • Vasculitis / pathology