Tumoral calcinosis. An ultrastructural analysis and consideration of pathogenesis

APMIS. 1988 Apr;96(4):368-76.


The clinical presentation and radiographic findings including computed tomography is described in a case of tumoral calcinosis along with a detailed light- and electronmicroscopic analysis. Five main cell types surrounding the calcified masses were identified: fat cells, fibroblasts, macrophages, osteoclast-like giant cells and osteoblast-like cells. The light microscopic and ultrastructural findings suggest an initial tissue damage with fat necrosis and the secondary calcification process seems to be of the mitochondrial type and possibly also of the matrix vesicel type.

Publication types

  • Case Reports

MeSH terms

  • Adipose Tissue / ultrastructure
  • Bone Diseases / diagnostic imaging
  • Bone Diseases / etiology
  • Bone Diseases / pathology*
  • Calcinosis / diagnostic imaging
  • Calcinosis / etiology
  • Calcinosis / pathology*
  • Diagnosis, Differential
  • Female
  • Femur
  • Fibroblasts / ultrastructure
  • Humans
  • Macrophages / ultrastructure
  • Microscopy, Electron
  • Middle Aged
  • Osteoblasts / ultrastructure
  • Osteoclasts / ultrastructure
  • Tomography, X-Ray Computed