The relationship between soma size and oxidative enzyme activity of motoneurones supplying the fast twitch muscle and the slow twitch muscle was examined. Horseradish peroxidase was injected into the extensor digitorum longus (fast twitch) muscle and the soleus (slow twitch) muscle to retrogradely label corresponding motoneurones of the rat spinal cord. There was a negative relation between soma size and oxidative enzyme activity of motoneurones in a particular neurone pool. The alpha motoneurones supplying the slow twitch muscle had higher oxidative enzyme activities than identical size motoneurones supplying the fast twitch muscle. The present results suggest that there is a difference between oxidative capacities of fast twitch and slow twitch neurone pools.