The great escape? SARS-CoV-2 variants evading neutralizing responses

Jérémie Prévost; Andrés Finzi

doi:10.1016/j.chom.2021.02.010

The great escape? SARS-CoV-2 variants evading neutralizing responses

Cell Host Microbe. 2021 Mar 10;29(3):322-324. doi: 10.1016/j.chom.2021.02.010.

Authors

Jérémie Prévost¹, Andrés Finzi²

Affiliations

¹ Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada.
² Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address: andres.finzi@umontreal.ca.

Abstract

In the latest issues of Cell Host & Microbe and Cell, three articles describe new mutations in the SARS-CoV-2 Spike receptor binding domain that escape neutralizing responses. These highlight the importance of surveillance of SARS-CoV-2 evolution to anticipate and manage new variants that could impact reinfection, vaccine efficacy, and immunotherapies.

MeSH terms

Antibodies, Neutralizing / immunology*
Antibodies, Viral / immunology
Binding Sites
COVID-19 / immunology
COVID-19 / virology*
Humans
Immune Evasion
Mutation
Protein Binding
Protein Domains
Receptors, Virus
SARS-CoV-2 / genetics
SARS-CoV-2 / immunology*
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology

Substances

Antibodies, Neutralizing
Antibodies, Viral
Receptors, Virus
Spike Glycoprotein, Coronavirus