The great escape? SARS-CoV-2 variants evading neutralizing responses

Cell Host Microbe. 2021 Mar 10;29(3):322-324. doi: 10.1016/j.chom.2021.02.010.

Abstract

In the latest issues of Cell Host & Microbe and Cell, three articles describe new mutations in the SARS-CoV-2 Spike receptor binding domain that escape neutralizing responses. These highlight the importance of surveillance of SARS-CoV-2 evolution to anticipate and manage new variants that could impact reinfection, vaccine efficacy, and immunotherapies.

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • Antibodies, Viral / immunology
  • Binding Sites
  • COVID-19 / immunology
  • COVID-19 / virology*
  • Humans
  • Immune Evasion
  • Mutation
  • Protein Binding
  • Protein Domains
  • Receptors, Virus
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology*
  • Spike Glycoprotein, Coronavirus / genetics
  • Spike Glycoprotein, Coronavirus / immunology

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Receptors, Virus
  • Spike Glycoprotein, Coronavirus

Supplementary concepts

  • SARS-CoV-2 variants