Liver Tumors in Pediatric Patients

Surg Oncol Clin N Am. 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006.


The most recent advance in the care of children diagnosed with hepatoblastoma and hepatocellular carcinoma is the Pediatric Hepatic International Tumor Trial, which opened to international enrollment in 2018. It is being conducted as a collaborative effort by the pediatric multicenter trial groups in North America, Europe, and the Far East. This international effort was catalyzed by a new unified global risk stratification system for hepatoblastoma, an international histopathologic consensus classification for pediatric liver tumors, and a revised 2017 collaborative update of the PRE-Treatment EXTent of disease radiographic based staging system.

Keywords: Biliary rhabdomyosarcoma; Focal nodular hyperplasia; Hepatoblastoma; Hepatocellular carcinoma; Infantile hemangioma; Malignant rhabdoid tumor of the liver; Mesenchymal hamartoma; PRETEXT; Undifferentiated embryonal sarcoma of the liver.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Hepatocellular* / epidemiology
  • Carcinoma, Hepatocellular* / therapy
  • Child
  • Hepatoblastoma* / epidemiology
  • Hepatoblastoma* / therapy
  • Humans
  • Liver Neoplasms* / therapy
  • Multicenter Studies as Topic