Involvement of lncRNAs in celiac disease pathogenesis

Int Rev Cell Mol Biol. 2021:358:241-264. doi: 10.1016/bs.ircmb.2020.10.004. Epub 2020 Nov 11.


Celiac disease (CD) is an immune-mediated disease that develops in genetically susceptible individuals upon gluten exposure. Human Leukocyte Antigen (HLA) genes in the Major Histocompatibility Complex (MHC) have been described to represent the 40% of the genetic risk to develop CD. Aiming to gain understanding of the genetic involvement in CD, high throughput studies have been performed, revealing that many CD-associated variants are located in non-coding regions, hindering the study of the functional implications of these single nucleotide polymorphisms (SNPs). In the last decade, long non-coding RNAs (lncRNAs) have been described to be influenced by disease-associated SNPs and to drive many important mechanisms involved in the development of inflammatory diseases. Here we describe the lncRNAs identified and characterized in the context of celiac disease and highlight the importance of the study of these molecules in inflammatory and autoimmune disorders.

Keywords: Celiac disease; Immune response; Inflammation; Long non-coding RNA; SNP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Celiac Disease / genetics*
  • Celiac Disease / immunology
  • Genetic Predisposition to Disease*
  • Humans
  • Immunity, Innate
  • Inflammation / genetics
  • RNA, Long Noncoding / genetics*
  • Tight Junctions / metabolism


  • RNA, Long Noncoding