The effects of menthol isomers on nasal sensation of airflow

Clin Otolaryngol Allied Sci. 1988 Feb;13(1):25-9. doi: 10.1111/j.1365-2273.1988.tb00277.x.


The effects of inhalation of L-menthol, D-isomenthol and D-neomenthol, upon nasal resistance and sensation to airflow were investigated in 40 subjects. L-menthol caused a highly significant enhancement of nasal sensation of airflow but despite their great similarity in structure and a similar peppermint smell the isomers D-isomenthol and D-neomenthol had no effect on nasal sensation of airflow. These findings show that L-menthol has a specific pharmacological action on nasal sensory nerve endings which is not related to its peppermint smell.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Airway Resistance / drug effects
  • Chemical Phenomena
  • Chemistry
  • Female
  • Humans
  • Male
  • Menthol / pharmacology*
  • Sensation / drug effects*
  • Sensory Receptor Cells / drug effects
  • Stereoisomerism


  • Menthol