From the discovery of DNA to current tools for DNA editing

J Exp Med. 2021 Apr 5;218(4):e20201791. doi: 10.1084/jem.20201791.

Abstract

In 1944, the Journal of Experimental Medicine published the groundbreaking discovery that DNA is the molecule holding genetic information (1944. J. Exp. Med.https://doi.org/10.1084/jem.79.2.137). This seminal finding was the genesis of molecular biology and the beginning of an incredible journey to understand, read, and manipulate the genetic code.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • CRISPR-Associated Protein 9 / history
  • CRISPR-Cas Systems
  • Clustered Regularly Interspaced Short Palindromic Repeats / genetics
  • Codon / history
  • DNA / history*
  • Gene Editing / history*
  • History, 20th Century
  • History, 21st Century
  • Humans

Substances

  • Codon
  • DNA
  • CRISPR-Associated Protein 9