MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens

Curr Eye Res. 1988 Feb;7(2):207-19. doi: 10.3109/02713688808995750.


A major protein with a molecular weight of 17,000, designated as MP17, has been identified in mammalian eye lens plasma membranes. Hydrophobic photolabeling experiments revealed that MP17 is a genuine intrinsic membrane protein. By using monoclonal antibodies we demonstrated that MP17 is not detectable in liver, heart, muscle, spleen and kidney, and thus can be considered, like MP26, as a lens-specific membrane protein. Furthermore, we showed that MP17 is a substrate for cAMP-dependent protein kinase and that it is a calmodulin-binding protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Calmodulin / metabolism
  • Cattle
  • Chemical Phenomena
  • Chemistry
  • Crystallins / metabolism
  • Eye Proteins / metabolism*
  • Lens, Crystalline / metabolism*
  • Membrane Proteins / metabolism*
  • Protein Biosynthesis
  • Protein Kinases / biosynthesis


  • Antibodies, Monoclonal
  • Calmodulin
  • Crystallins
  • Eye Proteins
  • Membrane Proteins
  • lens intrinsic protein MP 17
  • Protein Kinases