Environmental factors and chronic unexplained dyspepsia. Association with acetaminophen but not other analgesics, alcohol, coffee, tea, or smoking

Dig Dis Sci. 1988 Jun;33(6):641-8. doi: 10.1007/BF01540424.


A subgroup of patients with nonulcer dyspepsia (NUD) have no definite cause for their dyspepsia, termed essential dyspepsia. The aim of the present study was to determine if environmental factors are associated with essential dyspepsia. The patterns of ingestion of analgesic drugs (aspirin, acetaminophen, dextropropoxyphene), nonaspirin, nonsteroidal antiinflammatory drugs, alcohol, coffee, tea, and smoking in 113 essential dyspepsia patients were compared with 113 randomly selected community controls matched for age, sex, and social grade. Associations were studied in two six-month periods, before diagnosis in all patients and before the onset of NUD in those patients with a short history of dyspepsia. It was found that acetaminophen ingestion was associated with essential dyspepsia, and this association was present both before the onset of the dyspepsia (OR 3.1, 95% CI 1.3-7.1) and before diagnosis (OR 1.8, 95% CI 1.2-2.6). None of the other environmental factors were associated with essential dyspepsia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / adverse effects*
  • Analgesics / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Aspirin / adverse effects
  • Chronic Disease
  • Coffee / adverse effects*
  • Dextropropoxyphene / adverse effects
  • Dose-Response Relationship, Drug
  • Dyspepsia / diagnosis
  • Dyspepsia / etiology*
  • Ethanol / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Regression Analysis
  • Smoking / adverse effects*
  • Tea / adverse effects*


  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Coffee
  • Tea
  • Acetaminophen
  • Ethanol
  • Aspirin
  • Dextropropoxyphene