The concurrence of multiple sclerosis and glioblastoma

Mult Scler Relat Disord. 2021 May:50:102877. doi: 10.1016/j.msard.2021.102877. Epub 2021 Mar 2.


Introduction: Glioblastoma rarely coincides with multiple sclerosis. Although registries have reported a higher proportion of brain tumors-most of which are glial-these events appear to be underreported. The relative contribution of JC virus (an oncogenic virus) and disease modifying therapies that may facilitate JC virus neurotropism and tumor-specific immune evasion remain unknown.

Case report: We present the case of a 64-year-old woman who developed a primary glioblastoma eight years after diagnosis of multiple sclerosis while on dimethyl fumarate.

Conclusion: Systematic reporting may help answer whether JC virus seropositivity and certain disease modifying therapies confer higher risk for glioblastoma in patients with multiple sclerosis.

Keywords: Dimethyl fumarate; Glioblastoma; Histopathology; JC virus; Multiple sclerosis; Pharmacovigilance.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Dimethyl Fumarate
  • Female
  • Glioblastoma* / complications
  • Glioblastoma* / diagnostic imaging
  • Glioblastoma* / epidemiology
  • Humans
  • Immunosuppressive Agents
  • JC Virus*
  • Middle Aged
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / drug therapy
  • Multiple Sclerosis* / epidemiology
  • Multiple Sclerosis, Relapsing-Remitting*


  • Immunosuppressive Agents
  • Dimethyl Fumarate