Analysis of the results of patients treatment with metabolic syndrome, diabetic foot syndrome combined with diastolic dysfunction of the left ventricle

Myroslav Kritsak; Iryna Stechyshyn; Bohdana Pavliuk; Olena Prokopovych; Nataliya Chornij

Analysis of the results of patients treatment with metabolic syndrome, diabetic foot syndrome combined with diastolic dysfunction of the left ventricle

Pol Merkur Lekarski. 2021 Feb 24;49(289):32-34.

Authors

Myroslav Kritsak¹, Iryna Stechyshyn², Bohdana Pavliuk², Olena Prokopovych³, Nataliya Chornij⁴

Affiliations

¹ I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine: Department of Operative Surgery and Clinical Anatomy.
² I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine: Department of Pharmacy Management, Economics and Technology.
³ I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine: Department of the First Emergency Medical Aim and Emergency Medical Treatment.
⁴ I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine: Department of Therapeutic Dentistry.

PMID: 33713090

Abstract

Obesity is one of the most serious and common risk factors for cardiovascular disease that increases the risk of type 2 diabetes.

Aim: The aim of the study was to analyze the features of disorders of diastolic function of the left ventricle and the oxygenation of arterial and venous blood in patients with diabetic foot syndrome and metabolic syndrome with diastolic dysfunction of the left ventricle in its complex treatment with the using a course of hyperbaric oxygen therapy.

Materials and methods: An examination of 32 patients with diabetic foot syndrome, neuro-ischemic form (I stage - 8 patients, II stage - 24 patients) and metabolic syndrome, to determine an assessment was made of diastolic function of the left ventricle, determination of saturation of arterial and venous blood, oxygen content in arterial and venous blood, arterio-venous difference in oxygen. The control group consisted of 20 healthy individuals. These indicators were determined before starting the course of hyperbaric oxygen therapy and after completing the full course used 100 % oxygen, with the following parameters: working pressure of 1.7-1.8 at, with periods of compression and decompression of 10 minutes, isopression - 40-60 minutes. The total number of sessions was 8-10.

Results: The ratio peak rates of early- and late diastolic filling of the patients in the study group was significantly lower by 24.48 % (p <0.05) compared to the control group. Iso-volumetric relaxation and slowing of early diastolic filling also increased: by 21.02 % and by 7.26 % (p <0.05), respectively. Saturation of arterial blood after hyperbaric oxygenation sessions was 4.1% higher than the initial data. Saturation of venous blood before and after oxygen therapy was 52.64 ± 0.08 % and 58.25 ± 0.02 %, respectively. Oxygen content in arterial and venous blood before the start of the course was 121.57 ± 0.85 ml· L-1 and 127.20 ± 3.5 ml·L-1, respectively, and after treatment respectively 135.61 ± 0.06 ml·L-1 and 82.13 ± 0.01 ml·L-1. In addition, the volume of oxygen consumed by body tissues increased from 46.85 ± 0.84 ml·L-1 to 57.83 ± 4.3 ml·L-1.

Conclusions: The use of the course of the hyperbaric oxygen therapy contributed to the reduction of signs of diastolic heart failure and increased oxygenation rates of arterial and venous blood, the alignment of oxygen metabolism, contributed to the elimination of both systemic oxygen deficiency and local tissue hypoxia, due to which a complex therapeutic effect revealed.

Keywords: diabetes mellitus; hyperbaric oxygenation; obesity; oxygenation of blood.

MeSH terms

Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / therapy
Diabetic Foot* / therapy
Diastole
Heart Ventricles
Humans
Metabolic Syndrome* / complications
Metabolic Syndrome* / therapy