Cerebral Blood Flow in Chronic Kidney Disease

J Stroke Cerebrovasc Dis. 2021 Sep;30(9):105702. doi: 10.1016/j.jstrokecerebrovasdis.2021.105702. Epub 2021 Mar 11.


The prevalence of mild cognitive impairment increases with age and is further exacerbated by chronic kidney disease (CKD). CKD is associated with (1) mild cognitive impairment, (2) impaired endothelial function, (3) impaired blood-brain barrier, (4) increased cerebral microhemorrhage burden, (5) increased cerebral blood flow (CBF), (6) impaired cerebral autoregulation, (7) impaired cerebrovascular reactivity, and (8) increased arterial stiffness. We report preliminary findings from our group that demonstrate altered cerebrovascular reactivity in a mouse model of CKD-associated vascular calcification. The CBF of CKD mice increased more quickly in response to hypercapnia (p < 0.05) but then decreased prematurely during hypercapnia challenge (p < 0.05). Together, these results indicate that altered kidney function can lead to alterations in the cerebral microvasculature, and hence brain health.

Keywords: Cerebral blood flow; Chronic kidney disease; Laser speckle contrast imaging; Speckle contrast; Vascular dysfunction; Vasomotor reactivity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cerebral Arteries / physiopathology*
  • Cerebrovascular Circulation*
  • Cerebrovascular Disorders / etiology*
  • Cerebrovascular Disorders / physiopathology
  • Cognition
  • Cognitive Dysfunction / etiology
  • Cognitive Dysfunction / physiopathology
  • Cognitive Dysfunction / psychology
  • Disease Models, Animal
  • Female
  • Homeostasis
  • Humans
  • Hypercapnia / complications
  • Hypercapnia / physiopathology
  • Kidney / physiopathology*
  • Mice, Inbred DBA
  • Microcirculation
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / physiopathology