Unplanned implant removal in locally advanced breast cancer

Breast J. 2021 May;27(5):466-471. doi: 10.1111/tbj.14224. Epub 2021 Mar 14.


Study conducted to determine frequency and timing of unplanned breast implant removal after mastectomy, reconstruction, and postmastectomy radiation (PMRT). From 2010-2017, 52 patients underwent mastectomy, reconstruction, and PMRT. With median follow-up of 3.1 years, 23 patients (44%) experienced implant removal. Implant removal occurred in 9 (17%) patients before starting PMRT and 14 (27%) patients after starting PMRT. Implant removal rates were similar for hypofractionated PMRT compared with standard fractionation and for proton compared with photon PMRT. Implant removal is common for women undergoing mastectomy and reconstruction followed by PMRT. The risk is clinically significant even before starting radiation.

Keywords: breast cancer; implant removal; postmastectomy radiation.

MeSH terms

  • Breast Implants* / adverse effects
  • Breast Neoplasms* / radiotherapy
  • Breast Neoplasms* / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Mammaplasty* / adverse effects
  • Mastectomy
  • Postoperative Complications
  • Radiotherapy, Adjuvant
  • Treatment Outcome