The characteristics of nuclear membrane fluctuations in stem cells

J R Soc Interface. 2021 Mar;18(176):20201010. doi: 10.1098/rsif.2020.1010. Epub 2021 Mar 10.

Abstract

We analyse the stem cell nucleus shape fluctuation spectrum obtained from optical confocal microscopy on an hour time scale with 10 s resolution. In particular, we investigate the angular and time dependencies of these fluctuations, define appropriate correlation functions that reveal the fundamentally out of equilibrium nature of the observed fluctuations as well as their global anisotropy. Langevin equations respecting the symmetry of the system allow us to model the damped oscillatory behaviour of the time correlations.

Keywords: dynamics of stem cell nuclei; heterogeneity of the embryonic stem cell nucleus; nuclear membrane fluctuations.

MeSH terms

  • Anisotropy
  • Nuclear Envelope*
  • Stem Cells*