Longitudinal association of dietary fat intake with cardiovascular events in a prospective cohort study in Eastern Mediterranean region

Int J Food Sci Nutr. 2021 Dec;72(8):1095-1104. doi: 10.1080/09637486.2021.1895725. Epub 2021 Mar 9.


We examined the association of dietary fats intake with the 13-year risk of cardiovascular disease (CVD) among Iranian population. Totally 5432 participants of Isfahan Cohort Study (ICS) aged ≥ 35 years were included in the current study. The frequency of dietary fats including hydrogenated vegetables oil (HVO), non-hydrogenated vegetables oil (nHVO), olive oil, ghee, and animal fats during the preceding year were assessed using a validated food frequency questionnaire. After adjustment for potential confounders, individuals in the top quartile of HVO tended to have 68% greater risk for myocardial infarction compared with those in the first quartile (95% CI: 1.02, 2.78; P = 0.058). No association was found for other dietary fat sources with ischaemic heart disease, stroke, all-cause and CVD mortality after adjustment for all potential confounders. Higher consumption of HVO was associated with increased risk of myocardial infarction.

Keywords: Fatty acids; cardiovascular disease; fat; hydrogenated vegetables oil; oil.

MeSH terms

  • Cardiovascular Diseases* / epidemiology
  • Dietary Fats* / administration & dosage
  • Dietary Fats* / adverse effects
  • Humans
  • Iran / epidemiology
  • Myocardial Infarction* / epidemiology
  • Prospective Studies
  • Risk Factors


  • Dietary Fats