Exercise Is Muscle Mitochondrial Medicine

Exerc Sport Sci Rev. 2021 Apr 1;49(2):67-76. doi: 10.1249/JES.0000000000000250.


Exercise stimulates the biogenesis of mitochondria in muscle. Some literature supports the use of pharmaceuticals to enhance mitochondria as a substitute for exercise. We provide evidence that exercise rejuvenates mitochondrial function, thereby augmenting muscle health with age, in disease, and in the absence of cellular regulators. This illustrates the power of exercise to act as mitochondrial medicine in muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Exercise*
  • Humans
  • Mitochondria*
  • Muscles

Grants and funding