Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via the induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway

J BUON. 2021 Jan-Feb;26(1):293.

Abstract

The Editors of JBUON issue an Expression of Concern to 'Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway', by Dan Wang, Shuke Ge, Jichang Bai, Yongwei Song, JBUON 2018;23(2):340-345; PMID:29745074. Following the publication of the above article, readers drew to our attention that part of the data was possibly unreliable. We sent emails to the authors with a request to provide the raw data to prove the originality, but received no reply. Therefore, as we continue to work through the issues raised, we advise readers to interpret the information presented in the article with due caution. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.

Publication types

  • Expression of Concern

MeSH terms

  • Apoptosis
  • Cell Migration Inhibition / genetics*
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / pathology
  • HCT116 Cells
  • Humans
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction
  • Triterpenes / pharmacology
  • Triterpenes / therapeutic use*

Substances

  • Triterpenes
  • boswellic acid
  • Proto-Oncogene Proteins c-akt