Preface to the Special Issue "Presynaptic Dysfunction and Disease"

J Neurochem. 2021 Apr;157(2):102-106. doi: 10.1111/jnc.15319. Epub 2021 Mar 17.


The synapse is formed between a presynapse (which releases neurotransmitter) and the postsynapse (which transduces this chemical signal). Over the past decade, presynaptic dysfunction has emerged as a key mediator of a series of neurodevelopmental and neurodegenerative disorders. This special issue will highlight some of the important presynaptic molecules and mechanisms that are disrupted in these conditions and reveal potential routes for therapy.

Keywords: JNeurochem Special issue “Presynaptic Dysfunction and Disease”; calcium; neurodegeneration; neurodevelopmental disorder; neurotransmitter; presynapse; synaptic vesicle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neurodegenerative Diseases* / drug therapy
  • Neurodegenerative Diseases* / metabolism
  • Neurotransmitter Agents / metabolism*
  • Presynaptic Terminals / metabolism*
  • Synapses / metabolism*
  • Synaptic Vesicles / metabolism*


  • Neurotransmitter Agents