Roles of circRNAs in prostate cancer: Expression, mechanism, application and potential

Int J Biochem Cell Biol. 2021 May:134:105968. doi: 10.1016/j.biocel.2021.105968. Epub 2021 Mar 14.

Abstract

Circular RNA (circRNA) is a member of the non-coding RNA family that is formed by trans-splicing. Because of its unique structure and characteristics, it has extraordinary value for the diagnosis, treatment, and prognosis of diseases, particularly for tumors. Study of the role of circRNAs in the occurrence and development of prostate cancer has made considerable progress, but many areas remain that require further exploration and improvement. This article describes research into sequencing expression profiles, expression regulation, potential value as biomarkers, mechanism in the occurrence and development, therapy resistance, relationship with clinicopathological features, and prognostic value of circRNAs in prostate cancer from the past few years.

Keywords: Diagnosis; Prognosis; Prostate cancer; Therapy resistance; circRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism*
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Prognosis
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology*
  • RNA, Circular / genetics*
  • Receptors, Androgen / metabolism*

Substances

  • Biomarkers
  • MicroRNAs
  • RNA, Circular
  • Receptors, Androgen