Esophageal Epidermoid Metaplasia: Clinical Characteristics and Risk of Esophageal Squamous Neoplasia

Am J Gastroenterol. 2021 Jul 1;116(7):1533-1536. doi: 10.14309/ajg.0000000000001225.

Abstract

Introduction: Esophageal epidermoid metaplasia (EEM) is a rare disease.

Methods: Patients with EEM diagnosed between 2014 and 2020 were reviewed.

Results: Forty EEM cases were identified. EEM occurred in 9 (23%) patients before, concordant, or after esophageal squamous cell carcinoma (ESCC). EEM was associated with previous esophageal lichen planus in 5 patients, Barrett's esophagus 7, and esophageal adenocarcinoma 1. EEM was focal in 28 (70%) or diffuse in 12 (30%) and not detected in 45% on recent previous endoscopy.

Discussion: EEM is a premalignant underrecognized condition associated with multiple conditions. Close follow-up or endoscopic treatment may be warranted because of its ESCC association.

MeSH terms

  • Adenocarcinoma / epidemiology
  • Aged
  • Alcohol Drinking / epidemiology
  • Barrett Esophagus / epidemiology
  • Deglutition Disorders / physiopathology
  • Disease Progression
  • Endoscopy, Digestive System
  • Esophageal Diseases / epidemiology*
  • Esophageal Diseases / pathology
  • Esophageal Diseases / physiopathology
  • Esophageal Neoplasms / epidemiology*
  • Esophageal Squamous Cell Carcinoma / epidemiology*
  • Female
  • Gastroesophageal Reflux / epidemiology
  • Humans
  • Leukoplakia / epidemiology*
  • Leukoplakia / pathology
  • Leukoplakia / physiopathology
  • Lichen Planus / epidemiology
  • Male
  • Metaplasia
  • Middle Aged
  • Tobacco Use / epidemiology

Supplementary concepts

  • Adenocarcinoma Of Esophagus