Prognostic scoring models in parotid gland carcinoma

Head Neck. 2021 Jul;43(7):2081-2090. doi: 10.1002/hed.26672. Epub 2021 Mar 18.


Background: The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.

Methods: All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.

Results: The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.

Conclusion: Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.

Keywords: follow-up; parotid gland carcinoma; prognosis; prognostic scoring model; recurrence risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Parotid Gland / pathology
  • Parotid Gland / surgery
  • Parotid Neoplasms* / pathology
  • Parotid Neoplasms* / surgery
  • Prognosis
  • Retrospective Studies