The optical manipulation of tiny objects is significant to understand and to explore the unknown in the microworld, which has found many applications in materials science and life science. Physically speaking, these technologies arise from direct or indirect optomechanical coupling to convert incident optical energy to mechanical energy of target objects, while their efficiency and functionalities are determined by the coupling behavior. Traditional optical tweezers stem from direct light-to-matter momentum transfer, and the generation of an optical gradient force requires high optical power and rigorous optics. As a comparison, the opto-thermophoretic manipulation techniques proposed recently originate from high-efficiency opto-thermomechanical coupling and feature low optical power. Through rational design of the light-generated temperature gradient and exploring the mechanical response of diverse targets to the temperature gradient, a variety of opto-thermophoretic techniques were developed, which exhibit broad applicability to a wide range of target objects from colloid materials to biological cells to biomolecules. In this review, we will discuss the underlying mechanism of thermophoresis in different liquid environments, the cutting-edge technological innovation, and their applications in colloidal science and life science. We also provide a brief outlook on the existing challenges and anticipate their future development.
Keywords: colloidal matter; disease diagnosis; molecular analysis; molecule manipulation; optical assembly; optical manipulation; optical trapping; opto-thermophoretic manipulation; thermophoresis.