Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei

Exp Parasitol. 2021 May;224:108097. doi: 10.1016/j.exppara.2021.108097. Epub 2021 Mar 15.

Abstract

The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including the ameliorative effects of the compound on P. berghei-associated anaemia and organ damage were investigated. Mice were infected with chloroquine-sensitive strain of P. berghei and were treated with phytol at a dose of 10 and 20 mg/kg body weight (BW) for four days. The levels of parasitemia, packed cell volume and redox sensitive biomarkers of liver, brain and spleen tissues were determined. Our result revealed that phytol significantly (p < 0.05) suppressed the multiplication of P. berghei in a dose-dependent manner. Additionally, the phytol significantly (p < 0.05) ameliorated the P. berghei-induced anaemia and brain damage. Data from the present study demonstrated that phytol has suppressive effect on P. berghei and could ameliorate some P. berghei-induced pathological changes.

Keywords: Anaemia; Oxidative stress; Phytol; Plasmodium berghei.

MeSH terms

  • Analysis of Variance
  • Anemia / drug therapy
  • Anemia / parasitology
  • Animals
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use
  • Brain / parasitology
  • Brain / pathology
  • Chloroquine / pharmacology
  • Chloroquine / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Hematocrit
  • Liver / parasitology
  • Liver / pathology
  • Malaria / blood
  • Malaria / drug therapy*
  • Malaria / parasitology
  • Malaria / pathology
  • Male
  • Mice
  • Oxidation-Reduction / drug effects
  • Parasitemia / drug therapy
  • Phytol / pharmacology
  • Phytol / therapeutic use*
  • Plasmodium berghei / drug effects*
  • Random Allocation
  • Spleen / parasitology
  • Spleen / pathology

Substances

  • Antimalarials
  • Phytol
  • Chloroquine